InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cdh17

Summary

InnateDB Protein

IDBP-129668.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cdh17

Protein Name

cadherin 17

Synonyms

HPT-1; HPT-1/LI;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029871

InnateDB Gene

IDBG-129666 (Cdh17)

Protein Structure

UniProt Annotation

Function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. LI-cadherin may have a role in the morphological organization of liver and intestine.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Highest expression is found in intestine with lower expression in spleen, bone marrow, lung and testis. No expression detected in liver, kidney, heart, brain or skeletal muscle. Expressed in precursor B-cells and myeloid cells. {ECO:0000269PubMed:10906147}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005427	proton-dependent oligopeptide secondary active transmembrane transporter activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0006857	oligopeptide transport
GO:0007156	homophilic cell adhesion
GO:0016339	calcium-dependent cell-cell adhesion
GO:0035672	oligopeptide transmembrane transport