InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Npr3

Summary

InnateDB Protein

IDBP-129701.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Npr3

Protein Name

natriuretic peptide receptor 3

Synonyms

ANP-C; ANPR-C; EF-2; lgj; NPR-C; stri;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000066737

InnateDB Gene

IDBG-129699 (Npr3)

Protein Structure

UniProt Annotation

Function

Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. {ECO:0000269PubMed:10377427}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Note=Defects in Npr3 are the cause of a number of skeletal-overgrowth phenotypes, Longjohn (Lgj), Longjohn-2J (Lgj- 2J) and Strigosus (Stri). These are all recessive conditions characterized by an elongated body, thoracic kyphosis, arachnodactyly, and sacral and/or tail kinks, but no significant changes in craniofacial structures.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008528	G-protein coupled peptide receptor activity
GO:0016941	natriuretic peptide receptor activity
GO:0017046	peptide hormone binding
GO:0042562	hormone binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0001501	skeletal system development
GO:0002158	osteoclast proliferation
GO:0007193	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007194	negative regulation of adenylate cyclase activity
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0008217	regulation of blood pressure
GO:0030157	pancreatic juice secretion
GO:0033688	regulation of osteoblast proliferation
GO:0035810	positive regulation of urine volume
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0051000	positive regulation of nitric-oxide synthase activity