Version 5.4
Mus musculus Gene: Npr3
Summary
InnateDB Gene IDBG-129699.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Npr3
Gene Name natriuretic peptide receptor 3
Synonyms ANP-C; ANPR-C; EF-2; lgj; NPR-C; stri
Species Mus musculus
Ensembl Gene ENSMUSG00000022206
Encoded Proteins
IDBP-129701
natriuretic peptide receptor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000113389:
This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:11839896-11905674
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000066529 ENSMUSP00000066737
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008528 G-protein coupled peptide receptor activity
GO:0016941 natriuretic peptide receptor activity
GO:0017046 peptide hormone binding
GO:0042562 hormone binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001501 skeletal system development
GO:0002158 osteoclast proliferation
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007194 negative regulation of adenylate cyclase activity
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0008217 regulation of blood pressure
GO:0030157 pancreatic juice secretion
GO:0033688 regulation of osteoblast proliferation
GO:0035810 positive regulation of urine volume
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051000 positive regulation of nitric-oxide synthase activity
Cellular Component
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000113389
View Gene Order
ENSBTAG00000007665
Not yet available
Cross-References
SwissProt P70180
TrEMBL
UniProt Splice Variant
Entrez Gene 18162
UniGene Mm.25259 Mm.405462
RefSeq NM_001039181 NM_001286395 NM_008728 XM_006520028 XM_006520029 XM_006520031
OMIM
CCDS CCDS27386
HPRD
IMGT
MGI ID MGI:97373
MGI Symbol Npr3
EMBL AC134793 AF131861 AF131862 AF131864 CH466581 D78175 U72676
GenPept AAB51036 AAF00104 AAF00105 AAF00107 BAA11241 EDL03281
RNA Seq Atlas 18162

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca