InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pcsk1n

Summary

InnateDB Protein

IDBP-129788.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pcsk1n

Protein Name

proprotein convertase subtilisin/kexin type 1 inhibitor

Synonyms

AI848336; bLEN; KEP; lLEN; Pan3; PEN; PEN19; PEN20; proSAAS; SAAS; SAASCT;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000040342

InnateDB Gene

IDBG-129784 (Pcsk1n)

Protein Structure

UniProt Annotation

Function

May function in the control of the neuroendocrine secretory pathway. Proposed be a specific endogenous inhibitor of PCSK1. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domain, but not the processed peptides reduce PCSK1 activity in the endoplasmic reticulum and Golgi. It reduces the activity of the 87 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition. Slows down convertase-mediated processing of proopiomelanocortin and proenkephalin. May control the intracellular timing of PCSK1 rather than its total level of activity. The function of the processed secreted peptides is not known. {ECO:0000269PubMed:10632593, ECO:0000269PubMed:11719503, ECO:0000269PubMed:11742530}.

Subcellular Localization

Secreted. Golgi apparatus, trans-Golgi network.

Disease Associations

Tissue Specificity

Expressed in brain (mostly hypothalamus and pituitary) and gut. Expressed in trigeminal ganglia and neuroendocrine cell lines. PEN is expressed in pancreas, spinal cord and brain (most abundant in striatum, hippocampus, pons and medulla, and cortex) (at protein level). {ECO:0000269PubMed:10632593, ECO:0000269PubMed:11259501, ECO:0000269PubMed:16631141, ECO:0000269PubMed:9630436}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity

Biological Process

GO:0002021	response to dietary excess
GO:0007218	neuropeptide signaling pathway
GO:0009409	response to cold
GO:0010951	negative regulation of endopeptidase activity
GO:0016486	peptide hormone processing