InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Runx1t1

Summary

InnateDB Protein

IDBP-130067.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Runx1t1

Protein Name

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

Synonyms

Cbfa2t1h; ETO; MTG8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000095856

InnateDB Gene

IDBG-130061 (Runx1t1)

Protein Structure

UniProt Annotation

Function

Transcription regulator that excerts its function by binding to histone deacetylases and transcription factors. Can repress transactivation mediated by TCF12 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00440}. Note=Colocalizes with ATN1 in discrete nuclear dots. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	43 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0042803	protein homodimerization activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0010977	negative regulation of neuron projection development
GO:0045444	fat cell differentiation
GO:0051101	regulation of DNA binding

Cellular Component

GO:0005634	nucleus
GO:0017053	transcriptional repressor complex

Protein Structure and Domains

PDB ID

MGI:104793

InterPro

IPR002893 Zinc finger, MYND-type
IPR003894 TAFH/NHR1
IPR013289 Eight-Twenty-One
IPR013290 Myeloid transforming gene on chromosome 8 (MTG8)
IPR014896 NHR2-like

PFAM

PF01753
PF07531
PF08788

PRINTS

PR01875
PR01876

PIRSF

SMART

SM00549

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt