Version 5.4
Mus musculus Gene: Runx1t1
Summary
InnateDB Gene IDBG-130061.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Runx1t1
Gene Name runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
Synonyms Cbfa2t1h; ETO; MTG8
Species Mus musculus
Ensembl Gene ENSMUSG00000006586
Encoded Proteins
IDBP-130063
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-130065
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-130067
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
IDBP-624424
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000079102:
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5\'-region of the runt-related transcription factor 1 gene fused to the 3\'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:13743436-13893649
Strand Forward strand
Band A1
Transcripts
ENSMUST00000006761 ENSMUSP00000006761
ENSMUST00000098257 ENSMUSP00000095857
ENSMUST00000098256 ENSMUSP00000095856
ENSMUST00000105566 ENSMUSP00000127109
ENSMUST00000150583
ENSMUST00000139736
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 43 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 43 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0010977 negative regulation of neuron projection development
GO:0045444 fat cell differentiation
GO:0051101 regulation of DNA binding
Cellular Component
GO:0005634 nucleus
GO:0016363 nuclear matrix
GO:0017053 transcriptional repressor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000079102
View Gene Order
ENSBTAG00000017339
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu05221
Acute myeloid leukemia pathway
mmu05200
Pathways in cancer pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa05221
Acute myeloid leukemia pathway
hsa05200
Pathways in cancer pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B1AXH8
UniProt Splice Variant
Entrez Gene 12395
UniGene Mm.407696 Mm.447795 Mm.470961 Mm.4909
RefSeq NM_001111026 NM_001111027 NM_009822 XM_006537568 XM_006537569 XM_006537570 XM_006537571 XM_006537572
OMIM
CCDS CCDS51125 CCDS17978 CCDS51124
HPRD
IMGT
MGI ID MGI:104793
MGI Symbol Runx1t1
EMBL AL807804 AL824702 AL844572
GenPept
RNA Seq Atlas 12395

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca