Version 5.4
Mus musculus Protein: Asap2
Summary
InnateDB Protein IDBP-130104.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Asap2
Protein Name ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000088344
InnateDB Gene IDBG-130102 (Asap2)
Protein Structure
UniProt Annotation
Function Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Note=Colocalizes with F-actin and ARF6 in phagocytic cups.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0008060 ARF GTPase activator activity
GO:0008270 zinc ion binding
Biological Process
GO:0008150 biological_process
GO:0032312 regulation of ARF GTPase activity
GO:0043547 positive regulation of GTPase activity
Cellular Component
GO:0005575 cellular_component
GO:0005886 plasma membrane
GO:0032580 Golgi cisterna membrane
Protein Structure and Domains
PDB ID MGI:2685438
InterPro IPR001452 SH3 domain
IPR002110 Ankyrin repeat
IPR011511 Variant SH3 domain
IPR020683 Ankyrin repeat-containing domain
PFAM PF00018
PF14604
PF00023
PF13606
PF07653
PF11929
PF12796
PRINTS PR00452
PR01415
PIRSF
SMART SM00326
SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q7SIG6
PhosphoSite PhosphoSite-Q7SIG6
TrEMBL
UniProt Splice Variant
Entrez Gene 211914
UniGene Mm.487801
RefSeq
MGI ID 1DCQ
MGI Symbol Asap2
OMIM
CCDS
HPRD
IMGT
EMBL BC080847 BC096022
GenPept AAH80847 AAH96022

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca