InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Actn3

Summary

InnateDB Protein

IDBP-130130.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Actn3

Protein Name

actinin alpha 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000006626

InnateDB Gene

IDBG-130128 (Actn3)

Protein Structure

UniProt Annotation

Function

F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0030674	protein binding, bridging
GO:0042803	protein homodimerization activity
GO:0051015	actin filament binding

Biological Process

GO:0006936

muscle contraction

Cellular Component

GO:0005865	striated muscle thin filament
GO:0030017	sarcomere
GO:0030018	Z disc

Protein Structure and Domains

PDB ID

MGI:99678

InterPro

IPR001715 Calponin homology domain
IPR002017 Spectrin repeat
IPR002048 EF-hand domain
IPR014837 EF-hand, Ca insensitive
IPR018159 Spectrin/alpha-actinin
IPR022613 Calmodulin-regulated spectrin-associated protein, CH domain

PFAM