InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mgrn1

Summary

InnateDB Protein

IDBP-130137.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mgrn1

Protein Name

mahogunin, ring finger 1

Synonyms

2610042J20Rik; md; mKIAA0544; nc;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000023159

InnateDB Gene

IDBG-130131 (Mgrn1)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase. Mediates TSG101 monoubiquitination at multiple sites. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination (By similarity). {ECO:0000250}.

Subcellular Localization

Early endosome {ECO:0000269PubMed:19422019, ECO:0000269PubMed:19524515}. Note=The endosomal localization is dependent on the interaction with TSG101. {ECO:0000250}.Isoform 1: Cytoplasm. Cell membrane {ECO:0000250}.Isoform 5: Cytoplasm. Nucleus. Note=In the cytoplasm, predominantly localized to the perinuclear region and discrete vesicular structures. In the nucleus, broadly distributed, but excluded from nucleoli.

Disease Associations

Tissue Specificity

Widely expressed, with highest levels in brain, heart, kidney and liver. In the CNS, especially prominent in the Purkinje cells of the cerebellum. In the skin, expressed in the basal layer of the epidermis and hair follicles, primarily in the outer root sheath. Isoforms 1, 3, 4 and 5 are equally expressed in the liver. Isoforms 1, 3 and 4 are most abundant in brain, kidney and heart, respectively. {ECO:0000269PubMed:12438443, ECO:0000269PubMed:12560552, ECO:0000269PubMed:17083490, ECO:0000269PubMed:19524515}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0006513	protein monoubiquitination
GO:0008333	endosome to lysosome transport
GO:0043951	negative regulation of cAMP-mediated signaling
GO:0045744	negative regulation of G-protein coupled receptor protein signaling pathway