InnateDB Protein
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IDBP-13016.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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AZU1
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Protein Name
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azurocidin 1
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Synonyms
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AZAMP; AZU; CAP37; HBP; HUMAZUR; NAZC;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000233997
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InnateDB Gene
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IDBG-13012 (AZU1)
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Protein Structure
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Function |
This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram- negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G. {ECO:0000269PubMed:1399008, ECO:0000269PubMed:1937776}.
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Subcellular Localization |
Cytoplasmic granule. Note=Cytoplasmic granules of neutrophils.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001254
Peptidase S1
IPR001314
Peptidase S1A, chymotrypsin-type
IPR009003
Trypsin-like cysteine/serine peptidase domain
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PFAM |
PF00089
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PRINTS |
PR00722
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PIRSF |
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SMART |
SM00020
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TIGRFAMs |
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Modification |
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SwissProt |
P20160
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
566
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UniGene |
Hs.72885
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RefSeq |
NP_001691
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HUGO |
HGNC:913
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OMIM |
162815
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CCDS |
CCDS12044
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HPRD |
01221
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IMGT |
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EMBL |
AC004799
BC069495
BC093931
BC093933
M96326
X58794
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GenPept |
AAB59353
AAH69495
AAH93931
AAH93933
CAA41601
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