InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Wasl

Summary

InnateDB Protein

IDBP-130213.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Wasl

Protein Name

Wiskott-Aldrich syndrome-like (human)

Synonyms

2900021I12Rik; 3110031I02Rik; N-WASP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031695

InnateDB Gene

IDBG-130211 (Wasl)

Protein Structure

UniProt Annotation

Function

Involved in mitosis and cytokinesis, via its role in the regulation of actin polymerization (By similarity). Regulates actin polymerization by stimulating the actin-nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. {ECO:0000250, ECO:0000269PubMed:12871950}.

Subcellular Localization

Cytoplasm, cytoskeleton. Nucleus. Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	17 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006900	membrane budding
GO:0007015	actin filament organization
GO:0007067	mitotic nuclear division
GO:0009617	response to bacterium
GO:0016050	vesicle organization
GO:0030036	actin cytoskeleton organization
GO:0030050	vesicle transport along actin filament
GO:0032880	regulation of protein localization
GO:0034629	cellular protein complex localization
GO:0045010	actin nucleation
GO:0051491	positive regulation of filopodium assembly
GO:0051653	spindle localization
GO:2000370	positive regulation of clathrin-mediated endocytosis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016023	cytoplasmic membrane-bounded vesicle
GO:0030027	lamellipodium
GO:0030478	actin cap
GO:0070062	extracellular vesicular exosome