Version 5.4
Mus musculus Gene: Wasl
Summary
InnateDB Gene IDBG-130211.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Wasl
Gene Name Wiskott-Aldrich syndrome-like (human)
Synonyms 2900021I12Rik; 3110031I02Rik; N-WASP
Species Mus musculus
Ensembl Gene ENSMUSG00000029684
Encoded Proteins
IDBP-130213
Wiskott-Aldrich syndrome-like (human)
IDBP-130215
Wiskott-Aldrich syndrome-like (human)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106299:
The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. The WASL gene product is a homolog of WAS protein, however, unlike the latter, it is ubiquitously expressed and shows highest expression in neural tissues. It has been shown to bind Cdc42 directly, and induce formation of long actin microspikes. [provided by RefSeq, Jul 2008]
This gene encodes a member of the Wiskott-Aldrich syndrome (WAS) protein family. Wiskott-Aldrich syndrome proteins share similar domain structure, and associate with a variety of signaling molecules to alter the actin cytoskeleton. The encoded protein is highly expressed in neural tissues, and interacts with several proteins involved in cytoskeletal organization, including cell division control protein 42 (CDC42) and the actin-related protein-2/3 (ARP2/3) complex. The encoded protein may be involved in the formation of long actin microspikes, and in neurite extension. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:24613805-24665009
Strand Reverse strand
Band A3.1
Transcripts
ENSMUST00000031695 ENSMUSP00000031695
ENSMUST00000041737 ENSMUSP00000043968
ENSMUST00000173399
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 50 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006900 membrane budding
GO:0007015 actin filament organization
GO:0007067 mitotic nuclear division
GO:0009617 response to bacterium
GO:0016050 vesicle organization
GO:0030036 actin cytoskeleton organization
GO:0030050 vesicle transport along actin filament
GO:0032880 regulation of protein localization
GO:0034629 cellular protein complex localization
GO:0045010 actin nucleation
GO:0051491 positive regulation of filopodium assembly
GO:0051653 spindle localization
GO:2000370 positive regulation of clathrin-mediated endocytosis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0030027 lamellipodium
GO:0030478 actin cap
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000106299
View Gene Order
ENSBTAG00000004643
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_257032
Nephrin interactions pathway
REACT_204801
eNOS activation and regulation pathway
REACT_229826
Netrin-1 signaling pathway
REACT_215995
NOSTRIN mediated eNOS trafficking pathway
REACT_188937
Metabolism pathway
REACT_230745
Immune System pathway
REACT_248291
DCC mediated attractive signaling pathway
REACT_258158
EPH-Ephrin signaling pathway
REACT_257656
EPHB-mediated forward signaling pathway
REACT_261444
Axon guidance pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_188576
Developmental Biology pathway
REACT_208364
Metabolism of nitric oxide pathway
REACT_223082
Cell-Cell communication pathway
KEGG
mmu04810
Regulation of actin cytoskeleton pathway
mmu04520
Adherens junction pathway
mmu04666
Fc gamma R-mediated phagocytosis pathway
mmu04062
Chemokine signaling pathway pathway
mmu05100
Bacterial invasion of epithelial cells pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_12541
NOSTRIN mediated eNOS trafficking pathway
REACT_23832
Nephrin interactions pathway
REACT_22351
DCC mediated attractive signaling pathway
REACT_22237
Netrin-1 signaling pathway
REACT_111045
Developmental Biology pathway
REACT_111155
Cell-Cell communication pathway
REACT_12389
eNOS activation and regulation pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_6802
Innate Immune System pathway
REACT_12508
Metabolism of nitric oxide pathway
REACT_18266
Axon guidance pathway
REACT_6900
Immune System pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_111217
Metabolism pathway
REACT_215545
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_226967
NOSTRIN mediated eNOS trafficking pathway
REACT_226352
eNOS activation and regulation pathway
REACT_216118
DCC mediated attractive signaling pathway
REACT_220341
Metabolism of nitric oxide pathway
REACT_205744
Netrin-1 signaling pathway
REACT_211504
Nephrin interactions pathway
REACT_213138
Immune System pathway
REACT_248222
EPH-Ephrin signaling pathway
REACT_206475
Cell-Cell communication pathway
REACT_211475
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_203140
Axon guidance pathway
REACT_219139
Metabolism pathway
REACT_259381
EPHB-mediated forward signaling pathway
REACT_216714
Innate Immune System pathway
REACT_220844
Developmental Biology pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04520
Adherens junction pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04062
Chemokine signaling pathway pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa05131
Shigellosis pathway
INOH
PID NCI
nephrin_neph1_pathway
Nephrin/Neph1 signaling in the kidney podocyte
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
netrin_pathway
Netrin-mediated signaling events
erbb1_downstream_pathway
ErbB1 downstream signaling
fak_pathway
Signaling events mediated by focal adhesion kinase
ephbfwdpathway
EPHB forward signaling
cdc42_pathway
CDC42 signaling events
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt Q91YD9
TrEMBL Q3TXX8 Q3UGK7 Q3UMN0 Q3UQ99 Q3USR1 Q80VV6 Q9CXQ9
UniProt Splice Variant
Entrez Gene 73178
UniGene Mm.1574 Mm.400191
RefSeq NM_001167745 NM_028459
OMIM
CCDS CCDS19945 CCDS51727
HPRD
IMGT
MGI ID MGI:1920428
MGI Symbol Wasl
EMBL AC153635 AJ318416 AK014104 AK140189 AK142642 AK143969 AK144789 AK147881 AK159052 BC045202
GenPept AAH45202 BAB29159 BAE24270 BAE25143 BAE25639 BAE26068 BAE28201 BAE34786 CAC69994
RNA Seq Atlas 73178

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca