InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sumo1

Summary

InnateDB Protein

IDBP-130315.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sumo1

Protein Name

SMT3 suppressor of mif two 3 homolog 1 (yeast)

Synonyms

GMP1; PIC1; SENTRIN; SMT3; Smt3C; SMT3H3; SMTP3; SUMO-1; Ubl1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000088935

InnateDB Gene

IDBG-158495 (Sumo1)

Protein Structure

UniProt Annotation

Function

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. {ECO:0000269PubMed:16990542}.

Subcellular Localization

Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus, PML body {ECO:0000250}. Note=Recruited by BCL11A into the nuclear body.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 669 interaction(s) predicted by orthology.

Experimentally validated
Total	55 [view]
Protein-Protein	55 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	669 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0019789	SUMO ligase activity
GO:0031625	ubiquitin protein ligase binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006950	response to stress
GO:0016925	protein sumoylation
GO:0030578	PML body organization
GO:0031334	positive regulation of protein complex assembly
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043392	negative regulation of DNA binding
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0060021	palate development
GO:0090204	protein localization to nuclear pore

Cellular Component

GO:0001650	fibrillar center
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016604	nuclear body
GO:0016605	PML body
GO:0016607	nuclear speck
GO:0030425	dendrite
GO:0031965	nuclear membrane
GO:0045202	synapse