InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Grm8

Summary

InnateDB Protein

IDBP-130432.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grm8

Protein Name

glutamate receptor, metabotropic 8

Synonyms

A230002O04; Gprc1h; mGluR8;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000087998

InnateDB Gene

IDBG-130430 (Grm8)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Strongly expressed in olfactory bulb, accessory olfactory bulb, and mammillary body. Weaker expression in the retina, and in scattered cells in the cortex and hindbrain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001642	group III metabotropic glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0008066	glutamate receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007608	sensory perception of smell
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0035249	synaptic transmission, glutamatergic
GO:0051966	regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0042734	presynaptic membrane

Protein Structure and Domains

PDB ID

MGI:1351345

InterPro

IPR000144 GPCR, family 3, metabotropic glutamate receptor 8
IPR000162 GPCR, family 3, metabotropic glutamate receptor
IPR000337 GPCR, family 3
IPR001786 GPCR, family 3, metabotropic glutamate receptor 4
IPR001828 Extracellular ligand-binding receptor
IPR011500 GPCR, family 3, nine cysteines domain
IPR017978 GPCR, family 3, C-terminal
IPR028082 Periplasmic binding protein-like I

PFAM

PF01094
PF07562
PF00003

PRINTS

PR01058
PR00593
PR00248
PR01054

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P47743