InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Grm8

Summary

InnateDB Gene

IDBG-130430.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Grm8

Gene Name

glutamate receptor, metabotropic 8

Synonyms

A230002O04; Gprc1h; mGluR8

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024211

Encoded Proteins

IDBP-130432

glutamate receptor, metabotropic 8

IDBP-249891

glutamate receptor, metabotropic 8

IDBP-249893

glutamate receptor, metabotropic 8

IDBP-541885

glutamate receptor, metabotropic 8

IDBP-540213

glutamate receptor, metabotropic 8

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000179603:
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:27275121-28135178

Strand

Reverse strand

Band

A3.2

Transcripts

ENSMUST00000090512	ENSMUSP00000087998
ENSMUST00000115324	ENSMUSP00000110979
ENSMUST00000115323	ENSMUSP00000110978
ENSMUST00000131897	ENSMUSP00000120394
ENSMUST00000146727
ENSMUST00000132755	ENSMUSP00000118098

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001642	group III metabotropic glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0008066	glutamate receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007608	sensory perception of smell
GO:0030818	negative regulation of cAMP biosynthetic process
GO:0035249	synaptic transmission, glutamatergic
GO:0051966	regulation of synaptic transmission, glutamatergic