Version 5.4
Mus musculus Protein: Vip
Summary
InnateDB Protein IDBP-130463.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vip
Protein Name vasoactive intestinal polypeptide
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000019906
InnateDB Gene IDBG-130461 (Vip)
Protein Structure
UniProt Annotation
Function VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder.PHM-27 is a potent agonist of the calcitonin receptor CALCR, with similar efficacy as calcitonin (By similarity). PHM also causes vasodilation. {ECO:0000250}.
Subcellular Localization Secreted.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005179 hormone activity
GO:0005515 protein binding
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0007611 learning or memory
GO:0009966 regulation of signal transduction
GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
GO:0032880 regulation of protein localization
GO:0043066 negative regulation of apoptotic process
GO:0043267 negative regulation of potassium ion transport
GO:0045732 positive regulation of protein catabolic process
GO:0045909 positive regulation of vasodilation
GO:0048662 negative regulation of smooth muscle cell proliferation
GO:0051930 regulation of sensory perception of pain
GO:0060406 positive regulation of penile erection
Cellular Component
GO:0005576 extracellular region
GO:0043025 neuronal cell body
Protein Structure and Domains
PDB ID MGI:98933
InterPro IPR000532 Glucagon/GIP/secretin/VIP
PFAM PF00123
PRINTS PR00275
PIRSF
SMART SM00070
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P32648
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 22353
UniGene
RefSeq NP_035832
MGI ID
MGI Symbol Vip
OMIM
CCDS CCDS56682
HPRD
IMGT
EMBL AK018599 BC089511 X74297
GenPept AAH89511 BAB31301 CAA52350

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca