InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pkia

Summary

InnateDB Protein

IDBP-130475.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pkia

Protein Name

protein kinase inhibitor, alpha

Synonyms

AI415001; PKIalpha;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000028999

InnateDB Gene

IDBG-130473 (Pkia)

Protein Structure

UniProt Annotation

Function

Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains.

Subcellular Localization

Disease Associations

Tissue Specificity

Present at high levels in skeletal muscle and brain but is present at lower levels in heart, testis and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004862	cAMP-dependent protein kinase inhibitor activity
GO:0005515	protein binding
GO:0034236	protein kinase A catalytic subunit binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006469	negative regulation of protein kinase activity
GO:0010389	regulation of G2/M transition of mitotic cell cycle
GO:0042308	negative regulation of protein import into nucleus
GO:0043086	negative regulation of catalytic activity
GO:2000480	negative regulation of cAMP-dependent protein kinase activity