Version 5.4
Mus musculus Protein: Rnf125
Summary
InnateDB Protein IDBP-130478.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rnf125
Protein Name ring finger protein 125
Synonyms 4930553F04Rik;
Species Mus musculus
Ensembl Protein ENSMUSP00000058251
InnateDB Gene IDBG-130476 (Rnf125)
Protein Structure
UniProt Annotation
Function E3 ubiquitin-protein ligase that acts as a positive regulator of T-cell activation. E3 ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0002376 immune system process
GO:0008150 biological_process
GO:0016567 protein ubiquitination
Cellular Component
GO:0005575 cellular_component
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1914914
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D9R0
PhosphoSite PhosphoSite-Q9D9R0
TrEMBL
UniProt Splice Variant
Entrez Gene 67664
UniGene Mm.400478
RefSeq NP_080577
MGI ID
MGI Symbol Rnf125
OMIM
CCDS CCDS29088
HPRD
IMGT
EMBL AC138611 AK006569 AK050395 BC094290 BC116883 BC116887
GenPept AAH94290 AAI16884 AAI16888 BAB24656 BAC34234

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca