Version 5.4
Homo sapiens Protein: FAM105B
Summary
InnateDB Protein IDBP-13092.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAM105B
Protein Name family with sequence similarity 105, member B
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000284274
InnateDB Gene IDBG-13090 (FAM105B)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0002040 sprouting angiogenesis
GO:0006508 proteolysis
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0045087 innate immune response
GO:0050728 negative regulation of inflammatory response
GO:0060070 canonical Wnt signaling pathway
GO:0070431 nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:1990108 protein linear deubiquitination
Cellular Component
GO:0005737 cytoplasm
GO:0071797 LUBAC complex
Protein Structure and Domains
PDB ID
InterPro IPR023235 FAM105
IPR023236 FAM105A
IPR023237 FAM105B
PFAM
PRINTS PR02055
PR02056
PR02057
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96BN8
PhosphoSite PhosphoSite-Q96BN8
TrEMBL
UniProt Splice Variant
Entrez Gene 90268
UniGene Hs.630498
RefSeq NP_612357
HUGO HGNC:25118
OMIM 615712
CCDS CCDS43302
HPRD 14266
IMGT
EMBL AC010491 AK092203 BC007706 BC015392 CH471102
GenPept AAH07706 AAH15392 BAC03828 EAX08038 EAX08039

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca