InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Taf1b

Summary

InnateDB Protein

IDBP-130937.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Taf1b

Protein Name

TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B

Synonyms

4930408G01Rik; A230108M10Rik; TAFI68; Tafi86;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075339

InnateDB Gene

IDBG-130935 (Taf1b)

Protein Structure

UniProt Annotation

Function

Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3. {ECO:0000269PubMed:9050847}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001164	RNA polymerase I CORE element sequence-specific DNA binding
GO:0001187	RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001189	RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript
GO:0006355	regulation of transcription, DNA-templated
GO:0006360	transcription from RNA polymerase I promoter