Version 5.4
Mus musculus Gene: Taf1b
Summary
InnateDB Gene IDBG-130935.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Taf1b
Gene Name TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B
Synonyms 4930408G01Rik; A230108M10Rik; TAFI68; Tafi86
Species Mus musculus
Ensembl Gene ENSMUSG00000059669
Encoded Proteins
IDBP-130937
TATA box binding protein (Tbp)-associated factor, RNA polymerase I, B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000115750:
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:24498581-24558571
Strand Forward strand
Band A1.3
Transcripts
ENSMUST00000075954 ENSMUSP00000075339
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001164 RNA polymerase I CORE element sequence-specific DNA binding
GO:0001187 RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001189 RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript
GO:0006355 regulation of transcription, DNA-templated
GO:0006360 transcription from RNA polymerase I promoter
Cellular Component
GO:0000120 RNA polymerase I transcription factor complex
GO:0070062 extracellular vesicular exosome
GO:0070860 RNA polymerase I core factor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000115750
View Gene Order
ENSBTAG00000007543
Not yet available
Pathways
NETPATH
REACTOME
REACT_245058
RNA Polymerase I Transcription pathway
REACT_244415
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_257165
RNA Polymerase I Transcription Termination pathway
REACT_205737
Epigenetic regulation of gene expression pathway
REACT_224328
SIRT1 negatively regulates rRNA Expression pathway
REACT_233572
Gene Expression pathway
REACT_207809
Negative epigenetic regulation of rRNA expression pathway
REACT_232235
RNA Polymerase I Promoter Escape pathway
REACT_240511
RNA Polymerase I Promoter Clearance pathway
REACT_259097
RNA Polymerase I Chain Elongation pathway
REACT_235780
RNA Polymerase I Transcription Initiation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_1074
RNA Polymerase I Transcription Termination pathway
REACT_2204
RNA Polymerase I Chain Elongation pathway
REACT_1913
RNA Polymerase I Promoter Escape pathway
REACT_953
RNA Polymerase I Transcription Initiation pathway
REACT_1309
RNA Polymerase I Transcription pathway
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_1974
RNA Polymerase I Promoter Clearance pathway
REACT_200856
NoRC negatively regulates rRNA expression pathway
REACT_200827
SIRT1 negatively regulates rRNA Expression pathway
REACT_21352
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_71
Gene Expression pathway
REACT_200834
Negative epigenetic regulation of rRNA expression pathway
REACT_221445
RNA Polymerase I Transcription Termination pathway
REACT_217942
SIRT1 negatively regulates rRNA Expression pathway
REACT_213048
Epigenetic regulation of gene expression pathway
REACT_203707
RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription pathway
REACT_217354
RNA Polymerase I Promoter Escape pathway
REACT_207088
RNA Polymerase I Transcription pathway
REACT_226022
Gene Expression pathway
REACT_225163
RNA Polymerase I Chain Elongation pathway
REACT_208197
RNA Polymerase I Transcription Initiation pathway
REACT_215001
Negative epigenetic regulation of rRNA expression pathway
REACT_219488
RNA Polymerase I Promoter Clearance pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P97358
TrEMBL
UniProt Splice Variant
Entrez Gene 21340
UniGene Mm.39082
RefSeq NM_020614
OMIM
CCDS CCDS36419
HPRD
IMGT
MGI ID MGI:109577
MGI Symbol Taf1b
EMBL AC125067 AC132587 AK131963 AK165580 AK170313 BC057167 BC069907 BC094035 BC125027 BC125028 Y09973
GenPept AAH57167 AAH69907 AAH94035 AAI25028 AAI25029 BAE20906 BAE38271 BAE41709 CAA71092
RNA Seq Atlas 21340

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca