InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cngb3

Summary

InnateDB Protein

IDBP-130962.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cngb3

Protein Name

cyclic nucleotide gated channel beta 3

Synonyms

CCNC2; CNG6; Cngbeta2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000100064

InnateDB Gene

IDBG-130960 (Cngb3)

Protein Structure

UniProt Annotation

Function

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors. Essential for the generation of light-evoked electrical responses in the red-, green- and blue sensitive cones (By similarity). Induced a flickering channel gating, weakened the outward rectification in the presence of extracellular calcium, increased sensitivity for L-cis diltiazem and enhanced the cAMP efficacy of the channel when coexpressed with CNGA3. {ECO:0000250, ECO:0000269PubMed:10662822}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Small subset of retinal photorecptor cells and testis. {ECO:0000269PubMed:10662822}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005222	intracellular cAMP activated cation channel activity
GO:0005223	intracellular cGMP activated cation channel activity
GO:0005249	voltage-gated potassium channel activity
GO:0005515	protein binding
GO:0030553	cGMP binding

Biological Process

GO:0006812	cation transport
GO:0007601	visual perception
GO:0007603	phototransduction, visible light
GO:0009187	cyclic nucleotide metabolic process
GO:0042391	regulation of membrane potential
GO:0071805	potassium ion transmembrane transport

Cellular Component

GO:0001750	photoreceptor outer segment
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:1902495	transmembrane transporter complex