Version 5.4
Mus musculus Protein: Dtna
Summary
InnateDB Protein IDBP-131151.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dtna
Protein Name dystrobrevin alpha
Synonyms 2210407P21Rik; a-DB-1; adbn; Dtn; DTN-A; Gm19389;
Species Mus musculus
Ensembl Protein ENSMUSP00000037475
InnateDB Gene IDBG-131149 (Dtna)
Protein Structure
UniProt Annotation
Function Involved in synapse maturation and required for normal muscle function.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:14623885}. Cell junction, synapse {ECO:0000269PubMed:14623885}. Cell membrane {ECO:0000269PubMed:14623885}. Note=In peripheral nerves, colocalizes with MAGEE1 in the Schwann cell membrane.
Disease Associations
Tissue Specificity Expressed in skeletal muscle, heart, lung and brain. Sarcolemma and neuromuscular junction in skeletal muscle. Isoform 2 is restricted to the neuromuscular junction. Isoforms 5 and 6 are only expressed in muscle.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 17 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0016014 dystrobrevin complex
GO:0030054 cell junction
GO:0042383 sarcolemma
GO:0043234 protein complex
GO:0045202 synapse
Protein Structure and Domains
PDB ID MGI:106039
InterPro IPR000433 Zinc finger, ZZ-type
IPR015153 EF-hand domain, type 1
IPR015154 EF-hand domain, type 2
PFAM PF00569
PF09068
PF09069
PRINTS
PIRSF
SMART SM00291
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D2N4
PhosphoSite PhosphoSite-Q9D2N4
TrEMBL Q8BTD9
UniProt Splice Variant
Entrez Gene 13527
UniGene Mm.94371
RefSeq NP_034217
MGI ID
MGI Symbol Dtna
OMIM
CCDS CCDS29094
HPRD
IMGT
EMBL AF143542 AF143543 AF143544 AJ009669 AK003829 AK019477 X95226 X95227 Z79787 Z79788 Z79789 Z79790 Z79791 Z79792 Z79793 Z79794 Z79795 Z79796 Z79797
GenPept AAD33913 AAD33914 AAD33915 BAB31746 BAC25056 CAA08770 CAA64518 CAA64519 CAB02145

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca