InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cybb

Summary

InnateDB Protein

IDBP-131160.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cybb

Protein Name

cytochrome b-245, beta polypeptide

Synonyms

C88302; Cgd; CGD91-phox; Cyd; gp91-1; gp91phox; Nox2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000015484

InnateDB Gene

IDBG-131158 (Cybb)

Protein Structure

UniProt Annotation

Function

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. {ECO:0000269PubMed:24739962}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005244	voltage-gated ion channel activity
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006801	superoxide metabolic process
GO:0006811	ion transport
GO:0006954	inflammatory response
GO:0007584	response to nutrient
GO:0034765	regulation of ion transmembrane transport
GO:0042493	response to drug
GO:0042554	superoxide anion generation
GO:0050665	hydrogen peroxide biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005783	endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0030425	dendrite
GO:0043020	NADPH oxidase complex
GO:0043025	neuronal cell body

Protein Structure and Domains

PDB ID

MGI:88574

InterPro

IPR000778 Cytochrome b245, heavy chain
IPR008333 Oxidoreductase, FAD-binding domain
IPR013112 FAD-binding 8
IPR013121 Ferric reductase, NAD binding
IPR013130 Ferric reductase transmembrane component-like domain
IPR017938 Riboflavin synthase-like beta-barrel

PFAM

PF00970
PF08022
PF08030
PF01794

PRINTS

PR00466

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q61093