InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Map2k7

Summary

InnateDB Protein

IDBP-131172.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map2k7

Protein Name

mitogen-activated protein kinase kinase 7

Synonyms

5930412N11Rik; JNKK 2; Jnkk2; MAPKK 7; Mapkk7; MEK 7; Mek7; Mkk7; Prkmk7; sek2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000003027

InnateDB Gene

IDBG-131170 (Map2k7)

Protein Structure

UniProt Annotation

Function

Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K4/MKK4, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4/MKK4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The monophosphorylation of JNKs on the Thr residue is sufficient to increase JNK activity indicating that MAP2K7/MKK7 is important to trigger JNK activity, while the additional phosphorylation of the Tyr residue by MAP2K4/MKK4 ensures optimal JNK activation. Has a specific role in JNK signal transduction pathway activated by proinflammatory cytokines. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. {ECO:0000269PubMed:11390361, ECO:0000269PubMed:12624093, ECO:0000269PubMed:9312105, ECO:0000269PubMed:9384583, ECO:0000269PubMed:9405446, ECO:0000269PubMed:9535930, ECO:0000269PubMed:9891090}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9891090}. Cytoplasm {ECO:0000269PubMed:9891090}.

Disease Associations

Tissue Specificity

Expressed at high levels in brain, lung, liver, skeletal muscle, kidney, and testis and at lower levels in the heart and spleen. {ECO:0000269PubMed:9312105, ECO:0000269PubMed:9405446, ECO:0000269PubMed:9535930}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 41 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	41 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004708	MAP kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008545	JUN kinase kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding
GO:0019903	protein phosphatase binding
GO:0031435	mitogen-activated protein kinase kinase kinase binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0006950	response to stress
GO:0007254	JNK cascade
GO:0007257	activation of JUN kinase activity
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0043525	positive regulation of neuron apoptotic process
GO:0051403	stress-activated MAPK cascade
GO:0072709	cellular response to sorbitol

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Protein Structure and Domains

PDB ID

MGI:1346871

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt