InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rrm2

Summary

InnateDB Protein

IDBP-131194.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rrm2

Protein Name

ribonucleotide reductase M2

Synonyms

AA407299; R2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000020980

InnateDB Gene

IDBG-131192 (Rrm2)

Protein Structure

UniProt Annotation

Function

Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004748	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0006260	DNA replication
GO:0009186	deoxyribonucleoside diphosphate metabolic process
GO:0009262	deoxyribonucleotide metabolic process
GO:0009263	deoxyribonucleotide biosynthetic process
GO:0051259	protein oligomerization
GO:0051290	protein heterotetramerization
GO:0055114	oxidation-reduction process