InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fabp4

Summary

InnateDB Protein

IDBP-131209.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fabp4

Protein Name

fatty acid binding protein 4, adipocyte

Synonyms

422/aP2; ALBP/Ap2; Ap2; Lbpl;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000029041

InnateDB Gene

IDBG-131207 (Fabp4)

Protein Structure

UniProt Annotation

Function

Lipid transport protein in adipocytes. Binds both long chain fatty acids and retinoic acid. Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus. {ECO:0000269PubMed:12077340, ECO:0000269PubMed:16574478, ECO:0000269PubMed:17516629}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Depending on the nature of the ligand, a conformation change exposes a nuclear localization motif and the protein is transported into the nucleus. Subject to constitutive nuclear export.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0008289	lipid binding

Biological Process

GO:0001816	cytokine production
GO:0006469	negative regulation of protein kinase activity
GO:0006810	transport
GO:0042632	cholesterol homeostasis
GO:0045892	negative regulation of transcription, DNA-templated
GO:0050729	positive regulation of inflammatory response
GO:0050872	white fat cell differentiation
GO:0050873	brown fat cell differentiation
GO:0071285	cellular response to lithium ion