InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gbp4

Summary

InnateDB Protein

IDBP-131218.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Gbp4

Protein Name

guanylate binding protein 4

Synonyms

AW228052; Mag-2; mKIAA4245; Mpa-2; Mpa2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000098522

InnateDB Gene

IDBG-255437 (Gbp4)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001933	negative regulation of protein phosphorylation
GO:0006184	GTP catabolic process
GO:0031397	negative regulation of protein ubiquitination
GO:0032687	negative regulation of interferon-alpha production
GO:0042308	negative regulation of protein import into nucleus
GO:0050688	regulation of defense response to virus
GO:0071346	cellular response to interferon-gamma

Cellular Component

Protein Structure and Domains

PDB ID

MGI:97072

InterPro

IPR003191 Guanylate-binding protein, C-terminal
IPR015894 Guanylate-binding protein, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02841
PF02263

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-