InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Catsper1

Summary

InnateDB Protein

IDBP-131238.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Catsper1

Protein Name

cation channel, sperm associated 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000045430

InnateDB Gene

IDBG-131236 (Catsper1)

Protein Structure

UniProt Annotation

Function

Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization. Contrary to the human ortholog, not activated by progesterone. {ECO:0000269PubMed:11595941, ECO:0000269PubMed:14657352, ECO:0000269PubMed:16036917, ECO:0000269PubMed:16467839, ECO:0000269PubMed:17174296}.

Subcellular Localization

Cell projection, cilium, flagellum membrane {ECO:0000269PubMed:11595941}; Multi-pass membrane protein {ECO:0000269PubMed:11595941}. Note=Specifically located in the principal piece of sperm tail.

Disease Associations

Tissue Specificity

Testis-specific. {ECO:0000269PubMed:11595941}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005227	calcium activated cation channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0007342	fusion of sperm to egg plasma membrane
GO:0030154	cell differentiation
GO:0030317	sperm motility
GO:0034765	regulation of ion transmembrane transport
GO:0051924	regulation of calcium ion transport
GO:0055085	transmembrane transport
GO:0060296	regulation of cilium beat frequency involved in ciliary motility
GO:0070509	calcium ion import
GO:0086010	membrane depolarization during action potential