Version 5.4
Mus musculus Protein: Ggh
Summary
InnateDB Protein IDBP-131325.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ggh
Protein Name gamma-glutamyl hydrolase
Synonyms gamma-GH;
Species Mus musculus
Ensembl Protein ENSMUSP00000095843
InnateDB Gene IDBG-131323 (Ggh)
Protein Structure
UniProt Annotation
Function Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. Acts as endopeptidase. Lysosomal enzyme is activated by sulfhydryl compounds.
Subcellular Localization Secreted, extracellular space {ECO:0000250}. Lysosome {ECO:0000250}. Melanosome {ECO:0000250}. Note=While its intracellular location is primarily the lysosome, most of the enzyme activity is secreted. {ECO:0000250}.
Disease Associations
Tissue Specificity Isoform I (more expressed than isoform II in all tissues) is highly expressed in salivary gland, followed by kidney, liver, lung, stomach and uterus, and weakly expressed in small intestine, brain and fetal liver. Also expressed at a lower level in thymus, spleen and skeletal muscle. Also expressed in tumors.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0034722 gamma-glutamyl-peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006541 glutamine metabolic process
GO:0010043 response to zinc ion
GO:0032868 response to insulin
GO:0042493 response to drug
GO:0045471 response to ethanol
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005764 lysosome
GO:0005829 cytosol
GO:0042470 melanosome
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:1329035
InterPro IPR011697 Peptidase C26
IPR017926 Glutamine amidotransferase
IPR029062 Class I glutamine amidotransferase-like
PFAM PF07722
PF00117
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z0L8
PhosphoSite PhosphoSite-Q9Z0L8
TrEMBL
UniProt Splice Variant
Entrez Gene 14590
UniGene Mm.445534
RefSeq NP_034411
MGI ID
MGI Symbol Ggh
OMIM
CCDS CCDS51126
HPRD
IMGT
EMBL AF051102 AF051103 AF090725 AF090726 AF090727 AF090728 AF090729 AF090730 AF090731 AF090732 AL732527 CR931798
GenPept AAC70002 AAC70003 AAD47388 CAM18838 CAO78172

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca