Version 5.4
Mus musculus Protein: Flnc
Summary
InnateDB Protein IDBP-131336.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Flnc
Protein Name filamin C, gamma
Synonyms 1110055E19Rik; ABP-280; ABPL; Fln2;
Species Mus musculus
Ensembl Protein ENSMUSP00000087960
InnateDB Gene IDBG-131332 (Flnc)
Protein Structure
UniProt Annotation
Function Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. {ECO:0000269PubMed:16914736}.
Subcellular Localization Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemme (By similarity). Targeting to developing and mature Z lines is mediated by the intradomain insert (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 58 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 58 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
GO:0030506 ankyrin binding
Biological Process
GO:0030029 actin filament-based process
GO:0048747 muscle fiber development
Cellular Component
GO:0015629 actin cytoskeleton
GO:0016528 sarcoplasm
GO:0030018 Z disc
GO:0042383 sarcolemma
Protein Structure and Domains
PDB ID MGI:95557
InterPro IPR001298 Filamin/ABP280 repeat
IPR001715 Calponin homology domain
IPR014756 Immunoglobulin E-set
IPR017868 Filamin/ABP280 repeat-like
PFAM PF00307
PF00630
PRINTS
PIRSF
SMART SM00557
SM00033
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8VHX6
PhosphoSite PhosphoSite-Q8VHX6
TrEMBL Q3UXJ8
UniProt Splice Variant
Entrez Gene 68794
UniGene Mm.39046
RefSeq NP_001074654
MGI ID
MGI Symbol Flnc
OMIM
CCDS CCDS39452
HPRD
IMGT
EMBL AC044807 AF119148 AF353670 AK135523 BC052186 BC060276 BC151097 BC158128
GenPept AAF97411 AAH52186 AAH60276 AAI51098 AAI58129 AAL68446 BAE22565

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca