Version 5.4
Mus musculus Protein: Banf1
Summary
InnateDB Protein IDBP-131343.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Banf1
Protein Name barrier to autointegration factor 1
Synonyms Baf; Bcrp1; L2bp1/Baf;
Species Mus musculus
Ensembl Protein ENSMUSP00000025762
InnateDB Gene IDBG-131341 (Banf1)
Protein Structure
UniProt Annotation
Function Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}. Chromosome {ECO:0000250}. Note=Significantly enriched at the nuclear inner membrane, diffusely throughout the nucleus during interphase and concentrated at the chromosomes during the M-phase. The phosphorylated form (by VRK1) shows a cytoplasmic localization (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 54 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0015074 DNA integration
GO:0075713 establishment of integrated proviral latency
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1346330
InterPro IPR004122 Barrier- to-autointegration factor, BAF
PFAM PF02961
PRINTS
PIRSF
SMART SM01023
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O54962
PhosphoSite PhosphoSite-O54962
TrEMBL
UniProt Splice Variant
Entrez Gene 23825
UniGene
RefSeq NP_035923
MGI ID
MGI Symbol Banf1
OMIM
CCDS CCDS29458
HPRD
IMGT
EMBL AB025349 AF037080 AK003025 AK004212 AK010257 AK011079 AK011100 AK012588 AK088896 BC003709
GenPept AAC40032 AAH03709 BAA83102 BAB22518 BAB23223 BAB26800 BAB27383 BAB27397 BAB28337 BAC40639

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca