Version 5.4
Mus musculus Gene: Banf1
Summary
InnateDB Gene IDBG-131341.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Banf1
Gene Name barrier to autointegration factor 1
Synonyms Baf; Bcrp1; L2bp1/Baf
Species Mus musculus
Ensembl Gene ENSMUSG00000024844
Encoded Proteins
IDBP-131343
barrier to autointegration factor 1
IDBP-619838
barrier to autointegration factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175334:
The protein encoded by this gene was first identified by its ability to protect retroviruses from intramolecular integration and therefore promote intermolecular integration into the host cell genome. The protein forms a homodimer which localizes to both the nucleus and cytoplasm and is specifically associated with chromosomes during mitosis. This protein binds to double stranded DNA in a non-specific manner and also binds to LEM-domain containing proteins of the nuclear envelope. This protein is thought to facilitate nuclear reassembly by binding with both DNA and inner nuclear membrane proteins and thereby recruit chromatin to the nuclear periphery. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:5364641-5366645
Strand Reverse strand
Band A
Transcripts
ENSMUST00000025762 ENSMUSP00000025762
ENSMUST00000170010 ENSMUSP00000126202
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 54 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 54 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
Biological Process
GO:0015074 DNA integration
GO:0075713 establishment of integrated proviral latency
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000175334
View Gene Order
ENSBTAG00000031875
Not yet available
Pathways
NETPATH
REACTOME
REACT_196648
Nuclear Envelope Breakdown pathway
REACT_249770
Cell Cycle, Mitotic pathway
REACT_208002
Nuclear Envelope Reassembly pathway
REACT_188804
Cell Cycle pathway
REACT_241408
M Phase pathway
REACT_199403
Mitotic Metaphase and Anaphase pathway
REACT_210180
Initiation of Nuclear Envelope Reformation pathway
REACT_250557
Mitotic Prophase pathway
REACT_202512
Mitotic Anaphase pathway
REACT_221677
Clearance of Nuclear Envelope Membranes from Chromatin pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160251
Clearance of Nuclear Envelope Membranes from Chromatin pathway
REACT_160242
Initiation of Nuclear Envelope Reformation pathway
REACT_9406
APOBEC3G mediated resistance to HIV-1 infection pathway
REACT_7991
Vpr-mediated nuclear import of PICs pathway
REACT_9058
2-LTR circle formation pathway
REACT_6866
Autointegration results in viral DNA circles pathway
REACT_6918
Integration of provirus pathway
REACT_6266
Early Phase of HIV Life Cycle pathway
REACT_6757
Interactions of Vpr with host cellular proteins pathway
REACT_115566
Cell Cycle pathway
REACT_910
M Phase pathway
REACT_6256
HIV Life Cycle pathway
REACT_1275
Mitotic Anaphase pathway
REACT_765
Mitotic Prophase pathway
REACT_160113
Nuclear Envelope Reassembly pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_6185
HIV Infection pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_8990
Integration of viral DNA into host genomic DNA pathway
REACT_160255
Nuclear Envelope Breakdown pathway
REACT_116125
Disease pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
REACT_216366
M Phase pathway
REACT_215084
Mitotic Metaphase and Anaphase pathway
REACT_211185
Mitotic Anaphase pathway
REACT_209409
Nuclear Envelope Breakdown pathway
REACT_219742
Clearance of Nuclear Envelope Membranes from Chromatin pathway
REACT_215505
Cell Cycle, Mitotic pathway
REACT_223514
Initiation of Nuclear Envelope Reformation pathway
REACT_214934
Cell Cycle pathway
REACT_209852
Nuclear Envelope Reassembly pathway
REACT_211448
Mitotic Prophase pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O54962
TrEMBL
UniProt Splice Variant
Entrez Gene 23825
UniGene
RefSeq NM_001038231 NM_011793
OMIM
CCDS CCDS29458
HPRD
IMGT
MGI ID MGI:1346330
MGI Symbol Banf1
EMBL AB025349 AF037080 AK003025 AK004212 AK010257 AK011079 AK011100 AK012588 AK088896 BC003709
GenPept AAC40032 AAH03709 BAA83102 BAB22518 BAB23223 BAB26800 BAB27383 BAB27397 BAB28337 BAC40639
RNA Seq Atlas 23825

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca