InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fbxl7

Summary

InnateDB Protein

IDBP-131349.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxl7

Protein Name

F-box and leucine-rich repeat protein 7

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000061305

InnateDB Gene

IDBG-131347 (Fbxl7)

Protein Structure

UniProt Annotation

Function

Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of AURKA during mitosis, causing mitotic arrest. {ECO:0000269PubMed:22306998}.

Subcellular Localization

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:22306998}. Note=Localizes to the centrosome during spindle formation.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0008283	cell proliferation
GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process