InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Fbxl7

Summary

InnateDB Gene

IDBG-131347.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fbxl7

Gene Name

F-box and leucine-rich repeat protein 7

Synonyms

Species

Mus musculus

Ensembl Gene

ENSMUSG00000043556

Encoded Proteins

IDBP-131349

F-box and leucine-rich repeat protein 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000183580:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. [provided by RefSeq, Jul 2008]
This gene encodes a member of the F-box protein family which is characterized by a 42-48 amino acid motif, the F-box, which binds to the S-phase kinase-associated protein 1 (Skp1) protein. The F-box proteins constitute one of the four subunits of E3 ubiquitin protein ligases called SCFs (SKP1-Cul1-F-box), which play a role in phosphorylation-dependent ubiquitination of proteins. The F-box proteins are divided into 3 subfamilies based on the other domain in the protein: F-box proteins that also have a WD-40 domain (Fbws subfamily), F-box proteins that also have leucine-rich repeats (Fbls subfamily) and F-box proteins that contain other motifs or lack known protein-interaction domains (Fbxs subfamily). The protein encoded by this gene belongs to the Fbls subfamily. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:26543084-26895049

Strand

Reverse strand

Band

Transcripts

ENSMUST00000059204

ENSMUSP00000061305

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0007067	mitotic nuclear division
GO:0008283	cell proliferation
GO:0016567	protein ubiquitination
GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0019005	SCF ubiquitin ligase complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000183580

View Gene Order

ENSBTAG00000003219

Not yet available

Cross-References

SwissProt

Q5BJ29

TrEMBL

UniProt Splice Variant

Entrez Gene

448987

UniGene

Mm.253378

RefSeq

NM_176959 XM_006520106

OMIM

CCDS

CCDS37052

HPRD

IMGT

MGI ID

MGI:3052506

MGI Symbol

Fbxl7

EMBL

AK129227 BC091646

GenPept

AAH91646 BAC98037

RNA Seq Atlas

448987