InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Elavl1

Summary

InnateDB Protein

IDBP-131414.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Elavl1

Protein Name

ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)

Synonyms

2410055N02Rik; Hua; HUR; W91709;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000096549

InnateDB Gene

IDBG-131410 (Elavl1)

Protein Structure

UniProt Annotation

Function

RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability. Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation. Binds to poly-U elements and AU- rich elements (AREs) in the 3'-UTR of target mRNAs. Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro. With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA. {ECO:0000269PubMed:21402775, ECO:0000269PubMed:24394384}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Translocates into the cytoplasm following phosphorylation by MAPKAPK2. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 113 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	11 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	113 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding
GO:0017091	AU-rich element binding
GO:0019901	protein kinase binding
GO:0035925	mRNA 3'-UTR AU-rich region binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006417	regulation of translation
GO:0045727	positive regulation of translation
GO:0048255	mRNA stabilization
GO:0070935	3'-UTR-mediated mRNA stabilization
GO:2000036	regulation of stem cell maintenance