Version 5.4
Mus musculus Gene: Elavl1
Summary
InnateDB Gene IDBG-131410.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Elavl1
Gene Name ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)
Synonyms 2410055N02Rik; Hua; HUR; W91709
Species Mus musculus
Ensembl Gene ENSMUSG00000040028
Encoded Proteins
IDBP-131414
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 14981256
[Homo sapiens] ELAVL1 is a protein that binds to specific mRNA subsets, preferentially within 3' untranslated regions, and is a pivotal posttranscriptional regulator of gene expression.
PMID 17534146
[Homo sapiens] ELAVL1 is an RNA-binding protein can stabilize and/or regulate the translation of target mRNAs, thereby affecting the cellular responses to immune, proliferative, and damaging agents. It has a broad anti-apoptotic function where it increases the stability of a target mRNA encoding the pro-survival deacetylase SIRT1 and promotes the expression of mRNAs encoding BCL2 and MCL1, two major anti-apoptotic effectors.
PMID 25678110
[Homo sapiens] ELAVL1 is required for the stabilization of IFNB1 mRNA, and suppression of ELAVL1 leads to impaired expression of IFNB1 in response to poly(I:C) treatment.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000066044:
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3\' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:4284782-4325100
Strand Reverse strand
Band A1.1
Transcripts
ENSMUST00000098950 ENSMUSP00000096549
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 113 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 11 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 113 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0005515 protein binding
GO:0017091 AU-rich element binding
GO:0019901 protein kinase binding
GO:0035925 mRNA 3'-UTR AU-rich region binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006417 regulation of translation
GO:0045727 positive regulation of translation
GO:0048255 mRNA stabilization
GO:0070935 3'-UTR-mediated mRNA stabilization
GO:2000036 regulation of stem cell maintenance
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000066044
View Gene Order
ENSBTAG00000000613
Not yet available
Pathways
NETPATH
REACTOME
REACT_198687
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_198691
HuR stabilizes mRNA pathway
REACT_233572
Gene Expression pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_25218
HuR stabilizes mRNA pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P70372
TrEMBL Q8BTQ1
UniProt Splice Variant
Entrez Gene 15568
UniGene Mm.119162 Mm.470546 Mm.471920 Mm.477235
RefSeq NM_010485 XM_006508698
OMIM
CCDS CCDS22084
HPRD
IMGT
MGI ID MGI:1100851
MGI Symbol Elavl1
EMBL AK080365 AK089088 CH466566 U17595 U65735
GenPept AAA96941 AAB17967 BAC37892 BAC40744 EDL21996 EDL21997
RNA Seq Atlas 15568

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca