InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lass4

Summary

InnateDB Protein

IDBP-131519.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lass4

Protein Name

LAG1 homolog, ceramide synthase 4

Synonyms

2900019C14Rik; Lass4; Trh1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000008350

InnateDB Gene

IDBG-131517 (Lass4)

Protein Structure

UniProt Annotation

Function

May be either a bona fide (dihydro)ceramide synthase or a modulator of its activity. When overexpressed in cells is involved in the production of sphingolipids containing different fatty acid donors (N-linked stearoyl- (C18) or arachidoyl- (C20) ceramides) in a fumonisin B1-independent manner. {ECO:0000269PubMed:12912983}.

Subcellular Localization

Nucleus membrane {ECO:0000255PROSITE- ProRule:PRU00108}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane {ECO:0000269PubMed:12912983}; Multi-pass membrane protein {ECO:0000269PubMed:12912983}.

Disease Associations

Tissue Specificity

Ubiquitously expressed, with highest levels in skin. {ECO:0000269PubMed:12912983, ECO:0000269PubMed:15823095}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding
GO:0050291	sphingosine N-acyltransferase activity