InnateDB Protein
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IDBP-131656.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Rsad2
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Protein Name
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radical S-adenosyl methionine domain containing 2
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Synonyms
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2510004L01Rik; cig5; Vig1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000020970
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InnateDB Gene
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IDBG-131654 (Rsad2)
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Protein Structure
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Function |
Interferon-inducible iron-sulfur (4FE-4S) cluster- binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of viruses, including west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus and vesicular stomatitis virus (VSV). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphospate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins. {ECO:0000269PubMed:17686841, ECO:0000269PubMed:19047684, ECO:0000269PubMed:21435586, ECO:0000269PubMed:21880757}.
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Subcellular Localization |
Endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side. Lipid droplet.
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Disease Associations |
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Tissue Specificity |
Expressed at higher levels in atherosclerotic arteries than in normal arteries. {ECO:0000269PubMed:15890971}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
4
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1929628
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InterPro |
IPR006638
Elongator protein 3/MiaB/NifB
IPR007197
Radical SAM
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PFAM |
PF04055
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PRINTS |
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PIRSF |
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SMART |
SM00729
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CBB9
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PhosphoSite |
PhosphoSite-Q8CBB9
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
58185
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UniGene |
Mm.473306
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RefSeq |
NP_067359
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MGI ID |
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MGI Symbol |
Rsad2
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OMIM |
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CCDS |
CCDS25848
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HPRD |
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IMGT |
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EMBL |
AF236064
AF442152
AK036373
AK150069
AK150406
AK150425
AK150525
AK150616
AK150684
AK150731
AK150767
AK150783
AK150788
AK150812
AK150835
AK151140
AK151185
AK151191
AK151206
AK151286
AK151308
AK151339
AK151389
AK151410
AK151412
AK151414
AK151476
AK151502
AK151538
AK151767
AK151770
AK151825
AK151833
AK151846
AK151906
AK151909
AK151940
AK151954
AK151971
AK152050
AK152065
AK152075
AK152235
AK152239
AK152241
AK152310
AK152354
AK152493
AK152600
AK152601
AK152631
AK152644
AK152664
AK152796
AK152861
AK152880
AK152895
AK152934
AK152962
AK153003
AK153024
AK153062
AK153077
AK153078
AK153232
AK153234
AK153306
AK153318
AK153324
AK153435
AK153556
AK159147
BC057868
CT010378
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GenPept |
AAF60314
AAH57868
AAL50054
BAC29401
BAE29281
BAE29532
BAE29548
BAE29636
BAE29706
BAE29764
BAE29807
BAE29833
BAE29848
BAE29852
BAE29875
BAE29895
BAE30147
BAE30184
BAE30188
BAE30203
BAE30271
BAE30290
BAE30317
BAE30360
BAE30375
BAE30377
BAE30379
BAE30431
BAE30453
BAE30485
BAE30673
BAE30676
BAE30722
BAE30726
BAE30737
BAE30787
BAE30790
BAE30816
BAE30826
BAE30840
BAE30906
BAE30920
BAE30927
BAE31060
BAE31062
BAE31064
BAE31116
BAE31146
BAE31264
BAE31348
BAE31349
BAE31374
BAE31383
BAE31399
BAE31501
BAE31552
BAE31565
BAE31578
BAE31608
BAE31625
BAE31643
BAE31658
BAE31688
BAE31702
BAE31703
BAE31825
BAE31827
BAE31887
BAE31898
BAE31903
BAE31992
BAE32092
BAE34854
CAJ18585
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