InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Casp4

Summary

InnateDB Protein

IDBP-131659.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casp4

Protein Name

caspase 4, apoptosis-related cysteine peptidase

Synonyms

Casp11; Caspl; ich-3;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027012

InnateDB Gene

IDBG-131657 (Casp4)

Protein Structure

UniProt Annotation

Function

Involved in ER-stress induced apoptosis. Cleaves caspase-1 (By similarity). Involved in the activation cascade of caspases responsible for apoptosis execution. Promotes IL-1 beta processing by ICE, so may also have a role in inflammatory responses. {ECO:0000250}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000250}. Mitochondrion {ECO:0000250}.

Disease Associations

Tissue Specificity

Mostly expressed in lung and spleen; weaker in heart and lung; little in liver, skeletal muscle, kidney and testis. Not found in the brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0097110	scaffold protein binding

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0007015	actin filament organization
GO:0035234	ectopic germ cell programmed cell death
GO:0042981	regulation of apoptotic process
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0050727	regulation of inflammatory response
GO:0070269	pyroptosis
GO:0097194	execution phase of apoptosis

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005789	endoplasmic reticulum membrane
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043234	protein complex
GO:0072557	IPAF inflammasome complex
GO:0072559	NLRP3 inflammasome complex
GO:0097169	AIM2 inflammasome complex

Protein Structure and Domains

PDB ID

MGI:107700

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR001315 CARD domain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011029 Death-like domain
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core
IPR017350 Caspase, interleukin-1 beta convertase-type

PFAM

PF00619
PF00656

PRINTS

PR00376

PIRSF

PIRSF038001

SMART

SM00114
SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References