Version 5.4
Mus musculus Gene: Casp4
Summary
InnateDB Gene IDBG-131657.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Casp4
Gene Name caspase 4, apoptosis-related cysteine peptidase
Synonyms Casp11; Caspl; ich-3
Species Mus musculus
Ensembl Gene ENSMUSG00000033538
Encoded Proteins
IDBP-131659
caspase 4, apoptosis-related cysteine peptidase
IDBP-532813
caspase 4, apoptosis-related cysteine peptidase
IDBP-534810
caspase 4, apoptosis-related cysteine peptidase
IDBP-542585
caspase 4, apoptosis-related cysteine peptidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a caspase that is involved in apoptosis, cell migration, and the inflammatory response. Although its official nomenclature is Casp4, caspase 4, apoptosis-related cysteine peptidase, this gene and its encoded protein have historically been called caspase 11. [provided by RefSeq, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:5308828-5336783
Strand Forward strand
Band A1
Transcripts
ENSMUST00000027012 ENSMUSP00000027012
ENSMUST00000162846 ENSMUSP00000124402
ENSMUST00000152651
ENSMUST00000160064 ENSMUSP00000124249
ENSMUST00000160521
ENSMUST00000159461 ENSMUSP00000124535
ENSMUST00000163086
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004197 cysteine-type endopeptidase activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0008234 cysteine-type peptidase activity
GO:0097110 scaffold protein binding
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0007015 actin filament organization
GO:0035234 ectopic germ cell programmed cell death
GO:0042981 regulation of apoptotic process
GO:0050718 positive regulation of interleukin-1 beta secretion
GO:0050727 regulation of inflammatory response
GO:0070269 pyroptosis
GO:0097194 execution phase of apoptosis
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043234 protein complex
GO:0072557 IPAF inflammasome complex
GO:0072559 NLRP3 inflammasome complex
GO:0097169 AIM2 inflammasome complex
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 12363
UniGene Mm.1569
RefSeq NM_007609 XM_006509837
OMIM
CCDS CCDS22799
HPRD
IMGT
MGI ID MGI:107700
MGI Symbol Casp4
EMBL
GenPept
RNA Seq Atlas 12363

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca