InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Esr1

Summary

InnateDB Protein

IDBP-131665.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Esr1

Protein Name

estrogen receptor 1 (alpha)

Synonyms

AA420328; AU041214; ER-alpha; ER[a]; ERa; ERalpha; ESR; Estr; Estra; Nr3a1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000070070

InnateDB Gene

IDBG-131663 (Esr1)

Protein Structure

UniProt Annotation

Function

Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA- binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF- kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA- binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. {ECO:0000269PubMed:10207113, ECO:0000269PubMed:10840033}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00407}. Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cell membrane {ECO:0000250}. Note=Colocalizes with ZDHHC7 and ZDHHC21 in the Golgi apparatus where most probably palmitoylation occurs. Associated with the plasma membrane when palmitoylated. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 520 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	29 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	520 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001046	core promoter sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005496	steroid binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0030284	estrogen receptor activity
GO:0034056	estrogen response element binding
GO:0038052	estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0042802	identical protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001547	antral ovarian follicle growth
GO:0002064	epithelial cell development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008209	androgen metabolic process
GO:0008584	male gonad development
GO:0010629	negative regulation of gene expression
GO:0010863	positive regulation of phospholipase C activity
GO:0016049	cell growth
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0032355	response to estradiol
GO:0042981	regulation of apoptotic process
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043401	steroid hormone mediated signaling pathway
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043627	response to estrogen
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045839	negative regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048146	positive regulation of fibroblast proliferation
GO:0048386	positive regulation of retinoic acid receptor signaling pathway
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060065	uterus development
GO:0060068	vagina development
GO:0060523	prostate epithelial cord elongation
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687	regulation of branching involved in prostate gland morphogenesis
GO:0060745	mammary gland branching involved in pregnancy
GO:0060749	mammary gland alveolus development
GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation
GO:0071391	cellular response to estrogen stimulus
GO:0071392	cellular response to estradiol stimulus

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:1352467

InterPro

IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001292 Oestrogen receptor
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR008946 Nuclear hormone receptor, ligand-binding

PFAM

PF00104
PF02159
PF00105

PRINTS

PR00543
PR00047
PR00398

PIRSF

PIRSF500101

SMART

SM00430
SM00399

TIGRFAMs

Post-translational Modifications

Modification

Cross-References