InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Esr1

Summary

InnateDB Gene

IDBG-131663.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Esr1

Gene Name

estrogen receptor 1 (alpha)

Synonyms

AA420328; AU041214; ER-alpha; ER[a]; ERa; ERalpha; ESR; Estr; Estra; Nr3a1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000019768

Encoded Proteins

IDBP-131665

estrogen receptor 1 (alpha)

IDBP-270550

estrogen receptor 1 (alpha)

IDBP-270552

estrogen receptor 1 (alpha)

IDBP-270554

estrogen receptor 1 (alpha)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000091831:
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters. [provided by RefSeq, Jul 2008]
This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 10:4611593-5005614

Strand

Forward strand

Band

Transcripts

ENSMUST00000067086	ENSMUSP00000070070
ENSMUST00000105590	ENSMUSP00000101215
ENSMUST00000105589	ENSMUSP00000101214
ENSMUST00000105588	ENSMUSP00000101213
ENSMUST00000137012
ENSMUST00000127934
ENSMUST00000149195
ENSMUST00000138828
ENSMUST00000127145
ENSMUST00000133985

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 520 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	29 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	520 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001046	core promoter sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003707	steroid hormone receptor activity
GO:0004879	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005496	steroid binding
GO:0005515	protein binding
GO:0008013	beta-catenin binding
GO:0008134	transcription factor binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0030284	estrogen receptor activity
GO:0034056	estrogen response element binding
GO:0038052	estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0042802	identical protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001547	antral ovarian follicle growth
GO:0002064	epithelial cell development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0008209	androgen metabolic process
GO:0008584	male gonad development
GO:0010629	negative regulation of gene expression
GO:0010863	positive regulation of phospholipase C activity
GO:0016049	cell growth
GO:0030518	intracellular steroid hormone receptor signaling pathway
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0030522	intracellular receptor signaling pathway
GO:0032355	response to estradiol
GO:0042981	regulation of apoptotic process
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043401	steroid hormone mediated signaling pathway
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0043627	response to estrogen
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045839	negative regulation of mitosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048146	positive regulation of fibroblast proliferation
GO:0048386	positive regulation of retinoic acid receptor signaling pathway
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060065	uterus development
GO:0060068	vagina development
GO:0060523	prostate epithelial cord elongation
GO:0060527	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis
GO:0060687	regulation of branching involved in prostate gland morphogenesis
GO:0060745	mammary gland branching involved in pregnancy
GO:0060749	mammary gland alveolus development
GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation
GO:0071391	cellular response to estrogen stimulus
GO:0071392	cellular response to estradiol stimulus