InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Casp12

Summary

InnateDB Protein

IDBP-131697.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Casp12

Protein Name

caspase 12

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000027009

InnateDB Gene

IDBG-131695 (Casp12)

Protein Structure

UniProt Annotation

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Mainly expressed in skeletal muscle and lung.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity

Biological Process

GO:0006508	proteolysis
GO:0006915	apoptotic process
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0042981	regulation of apoptotic process
GO:0070059	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum

Protein Structure and Domains

PDB ID

MGI:1312922

InterPro

IPR001309 Peptidase C14, ICE, catalytic subunit p20
IPR001315 CARD domain
IPR002138 Peptidase C14, caspase non-catalytic subunit p10
IPR011029 Death-like domain
IPR011600 Peptidase C14, caspase domain
IPR015917 Peptidase C14A, caspase precursor p45, core
IPR017350 Caspase, interleukin-1 beta convertase-type

PFAM

PF00619
PF00656

PRINTS

PR00376

PIRSF

PIRSF038001

SMART

SM00114
SM00115

TIGRFAMs

Post-translational Modifications

Modification

Cross-References