InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Elp2

Summary

InnateDB Protein

IDBP-131734.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Elp2

Protein Name

elongation protein 2 homolog (S. cerevisiae)

Synonyms

AU023723; Epl2; Statip1; StIP1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025120

InnateDB Gene

IDBG-131732 (Elp2)

Protein Structure

UniProt Annotation

Function

Regulates the ligand-dependent activation of STAT3. {ECO:0000269PubMed:10954736}.Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4 (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0019901	protein kinase binding
GO:0061133	endopeptidase activator activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006368	transcription elongation from RNA polymerase II promoter
GO:0010950	positive regulation of endopeptidase activity
GO:0043248	proteasome assembly
GO:0046425	regulation of JAK-STAT cascade