InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pdhb

Summary

InnateDB Protein

IDBP-131774.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdhb

Protein Name

pyruvate dehydrogenase (lipoamide) beta

Synonyms

2610103L06Rik; AL024199; C81408;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000022268

InnateDB Gene

IDBG-131772 (Pdhb)

Protein Structure

UniProt Annotation

Function

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. {ECO:0000250}.

Subcellular Localization

Mitochondrion matrix {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004738	pyruvate dehydrogenase activity
GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity
GO:0005515	protein binding

Biological Process

GO:0006006	glucose metabolic process
GO:0006086	acetyl-CoA biosynthetic process from pyruvate
GO:0006099	tricarboxylic acid cycle
GO:0008152	metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0045254	pyruvate dehydrogenase complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1915513

InterPro

IPR005475 Transketolase-like, pyrimidine-binding domain
IPR005476 Transketolase, C-terminal
IPR009014 Transketolase, C-terminal/Pyruvate-ferredoxin oxidoreductase, domain II
IPR029061 Thiamin diphosphate-binding fold

PFAM

PF02779
PF02780

PRINTS

PIRSF

SMART

SM00861

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9D051