InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pdhb

Summary

InnateDB Gene

IDBG-131772.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pdhb

Gene Name

pyruvate dehydrogenase (lipoamide) beta

Synonyms

2610103L06Rik; AL024199; C81408

Species

Mus musculus

Ensembl Gene

ENSMUSG00000021748

Encoded Proteins

IDBP-131774

pyruvate dehydrogenase (lipoamide) beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000168291:
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:8165991-8172992

Strand

Reverse strand

Band

Transcripts

ENSMUST00000022268

ENSMUSP00000022268

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004738	pyruvate dehydrogenase activity
GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity
GO:0005515	protein binding

Biological Process

GO:0006006	glucose metabolic process
GO:0006086	acetyl-CoA biosynthetic process from pyruvate
GO:0006099	tricarboxylic acid cycle
GO:0008152	metabolic process

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0045254	pyruvate dehydrogenase complex
GO:0070062	extracellular vesicular exosome