InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sox11

Summary

InnateDB Protein

IDBP-131876.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sox11

Protein Name

SRY-box containing gene 11

Synonyms

1110038H03Rik; 6230403H02Rik; AI836553; end1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000078070

InnateDB Gene

IDBG-131874 (Sox11)

Protein Structure

UniProt Annotation

Function

Probably important in the developing nervous system. May also have a role in tissue modeling during development.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00267, ECO:0000269PubMed:15456859}.

Disease Associations

Tissue Specificity

Expression prominent in the periventricular cells of the central nervous system, also observed in a wide range of tissues involved in epithelial-mesenchymal interactions.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000976	transcription regulatory region sequence-specific DNA binding
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0001071	nucleic acid binding transcription factor activity
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0001158	enhancer sequence-specific DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008135	translation factor activity, nucleic acid binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001501	skeletal system development
GO:0001822	kidney development
GO:0001841	neural tube formation
GO:0002089	lens morphogenesis in camera-type eye
GO:0003151	outflow tract morphogenesis
GO:0003211	cardiac ventricle formation
GO:0003357	noradrenergic neuron differentiation
GO:0006366	transcription from RNA polymerase II promoter
GO:0006412	translation
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0014003	oligodendrocyte development
GO:0014009	glial cell proliferation
GO:0014032	neural crest cell development
GO:0017015	regulation of transforming growth factor beta receptor signaling pathway
GO:0021510	spinal cord development
GO:0021782	glial cell development
GO:0030182	neuron differentiation
GO:0030513	positive regulation of BMP signaling pathway
GO:0035332	positive regulation of hippo signaling cascade
GO:0035914	skeletal muscle cell differentiation
GO:0045666	positive regulation of neuron differentiation
GO:0045669	positive regulation of osteoblast differentiation
GO:0045778	positive regulation of ossification
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046887	positive regulation of hormone secretion
GO:0048485	sympathetic nervous system development
GO:0048557	embryonic digestive tract morphogenesis
GO:0048704	embryonic skeletal system morphogenesis
GO:0050672	negative regulation of lymphocyte proliferation
GO:0050769	positive regulation of neurogenesis
GO:0060022	hard palate development
GO:0060023	soft palate development
GO:0060174	limb bud formation
GO:0060253	negative regulation of glial cell proliferation
GO:0060412	ventricular septum morphogenesis
GO:0060425	lung morphogenesis
GO:0060548	negative regulation of cell death
GO:0060563	neuroepithelial cell differentiation
GO:0061029	eyelid development in camera-type eye
GO:0061053	somite development
GO:0061303	cornea development in camera-type eye
GO:0061386	closure of optic fissure
GO:0072395	signal transduction involved in cell cycle checkpoint
GO:2000648	positive regulation of stem cell proliferation
GO:2000678	negative regulation of transcription regulatory region DNA binding
GO:2001111	positive regulation of lens epithelial cell proliferation