InnateDB Protein
|
IDBP-131894.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Rb1cc1
|
Protein Name
|
RB1-inducible coiled-coil 1
|
Synonyms
|
2900055E04Rik; 5930404L04Rik; Cc1; FIP200; LaXp180;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000027040
|
InnateDB Gene
|
IDBG-131892 (Rb1cc1)
|
Protein Structure
|
|
Function |
Implicated in the regulation of RB1 expression. Functions as a DNA-binding transcription factor. Is a potent regulator of the RB1 pathway and a novel mediator that plays a crucial role in muscular differentiation. Expression is, thus, a prerequisite for myogenic differentiation. Inhibits PTK2/FAK1 and PTK2B/PYK2 activity and activation of downstream signaling pathways (By similarity). Plays a role as a modulator of TGF-beta- signaling by restricting substrate specificity of rnf111. Involved in autophagy. Regulates early events but also late events of autophagosome formation through direct interaction with Atg16L1. Required for the formation of the autophagosome-like double- membrane structure that surrounds the Salmonella-containing vacuole (SCV) duting S.typhimurium infection and subsequent xenophagy. Autophagy positively regulates repair of DNA damage induced by ionizing radiation and negatively regulates apoptosis. Plays an indispensible role in fetal hematopoiesis and in the regulation of neuronal homeostasis. {ECO:0000250, ECO:0000269PubMed:12095676, ECO:0000269PubMed:15968549, ECO:0000269PubMed:19258318, ECO:0000269PubMed:19940130, ECO:0000269PubMed:21088496, ECO:0000269PubMed:21525242, ECO:0000269PubMed:21795712, ECO:0000269PubMed:21807966, ECO:0000269PubMed:23285000, ECO:0000269PubMed:23392225}.
|
Subcellular Localization |
Nucleus. Cytoplasm, cytosol. Preautophagosomal structure. Note=Under starvation conditions, is localized to puncate structures primarily representing the isolation membrane that sequesters a portion of the cytoplasm resulting in the formation of an autophagosome.
|
Disease Associations |
|
Tissue Specificity |
Expressed abundantly in heart and testis, and moderately in kidney, liver and skeletal muscles. Very low expression levels in lung and spleen. Colocalizes with RB1 in various tissues. {ECO:0000269PubMed:12095676}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.
Experimentally validated |
Total |
15
[view]
|
Protein-Protein |
14
[view]
|
Protein-DNA |
1
[view]
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
47 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1341850
|
InterPro |
IPR019460
Autophagy-related protein 11
IPR029071
Ubiquitin-related domain
|
PFAM |
PF10377
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q9ESK9
|
PhosphoSite |
PhosphoSite-Q9ESK9
|
TrEMBL |
E0CZG6
|
UniProt Splice Variant |
|
Entrez Gene |
12421
|
UniGene |
Mm.489285
|
RefSeq |
NP_033956
|
MGI ID |
|
MGI Symbol |
Rb1cc1
|
OMIM |
|
CCDS |
CCDS35507
|
HPRD |
|
IMGT |
|
EMBL |
AB050017
AB070619
AC102781
AC139064
AJ242720
AK041038
AK159066
X82318
|
GenPept |
BAB16846
BAB85610
BAC30793
BAE34792
CAA57761
CAB92238
|
|
|