InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rb1cc1

Summary

InnateDB Gene

IDBG-131892.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rb1cc1

Gene Name

RB1-inducible coiled-coil 1

Synonyms

2900055E04Rik; 5930404L04Rik; Cc1; FIP200; LaXp180

Species

Mus musculus

Ensembl Gene

ENSMUSG00000025907

Encoded Proteins

IDBP-131894

RB1-inducible coiled-coil 1

IDBP-539083

RB1-inducible coiled-coil 1

IDBP-541655

RB1-inducible coiled-coil 1

IDBP-540896

RB1-inducible coiled-coil 1

IDBP-541410

RB1-inducible coiled-coil 1

IDBP-540893

RB1-inducible coiled-coil 1

IDBP-539726

RB1-inducible coiled-coil 1

IDBP-540891

RB1-inducible coiled-coil 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000023287:
The protein encoded by this gene interacts with signaling pathways to coordinately regulate cell growth, cell proliferation, apoptosis, autophagy, and cell migration. This tumor suppressor also enhances retinoblastoma 1 gene expression in cancer cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:6206197-6276648

Strand

Forward strand

Band

Transcripts

ENSMUST00000027040	ENSMUSP00000027040
ENSMUST00000159906	ENSMUSP00000125396
ENSMUST00000160871	ENSMUSP00000123768
ENSMUST00000162210
ENSMUST00000160062	ENSMUSP00000123876
ENSMUST00000162795	ENSMUSP00000124676
ENSMUST00000161327	ENSMUSP00000125348
ENSMUST00000159802
ENSMUST00000162257	ENSMUSP00000125334
ENSMUST00000159206
ENSMUST00000159661
ENSMUST00000161183
ENSMUST00000159349
ENSMUST00000159530	ENSMUSP00000124220
ENSMUST00000162418
ENSMUST00000159656

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 47 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	14 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	47 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0001889	liver development
GO:0001934	positive regulation of protein phosphorylation
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007049	cell cycle
GO:0007254	JNK cascade
GO:0007507	heart development
GO:0010506	regulation of autophagy
GO:0043066	negative regulation of apoptotic process
GO:0045793	positive regulation of cell size
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0000407	pre-autophagosomal structure
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031965	nuclear membrane
GO:0034045	pre-autophagosomal structure membrane
GO:0070969	ULK1-ATG13-FIP200 complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000023287

View Gene Order

ENSBTAG00000000878

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

mtor_4pathway

mTOR signaling pathway

Cross-References

SwissProt

TrEMBL

E0CYU7 E0CZG6

UniProt Splice Variant

Entrez Gene

12421

UniGene

Mm.293811 Mm.467912 Mm.471724 Mm.489285

RefSeq

NM_009826 XM_006495443

OMIM

CCDS

CCDS35507

HPRD

IMGT

MGI ID

MGI:1341850

MGI Symbol

Rb1cc1

EMBL

AC102781 AC139064

GenPept

RNA Seq Atlas

12421